Protein surface recognition via chemically enhanced phage display

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United States of America Patent

PATENT NO 12116698
SERIAL NO

17004403

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Abstract

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Low molecular weight molecules able to penetrate cells and tissues and having high specificity and affinity for the surfaces of proteins. Methods of making same, pharmaceutical compositions comprising same, and methods of treating cancers, infectious diseases, and diseases and disorders associated with aberrant protein expression using same. A method for selecting a therapeutic peptide for binding to an isolated and/or purified protein of interest by screening a phage display library containing phage particles with phage display peptides which have at least one APBA modified cysteine residue. The APBA modified cysteine residues bind to surface lysine residues on the isolated and/or purified protein of interest by dynamic covalent conjugation to form iminoboronates.

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Patent OwnerAddress
THE TRUSTEES OF BOSTON COLLEGE140 COMMONWEALTH AVENUE CHESTNUT HILL MA 02467

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gao, Jianmin Newton, US 26 289

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