Dendritic detergents for the analysis of proteins by mass spectrometry

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United States of America Patent

PATENT NO 12122805
APP PUB NO 20210188902A1
SERIAL NO

17272614

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Abstract

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A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a dendritic detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; vaporising the solution using the nanoelectrospray ionisation source; ionising the protein; resolving the ionised protein using the mass analyser; and detecting the resolved protein using the detector. A method of extracting a membrane protein from its native membrane comprises: providing a membrane protein in its native membrane; contacting the membrane protein with a dendritic detergent. Dendritic detergents for use in the methods are also provided.

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Patent OwnerAddress
FREIE UNIVERSITAT BERLIN14195 BERLIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ehrmann, Svenja Christina Berlin, DE 1 0
Haag, Rainer Berlin, DE 34 103
Liko, Idlir Oxford, GB 1 0
Pagel, Kevin Berlin, DE 3 5
Robinson, Carol V Oxford, GB 4 1
Urner, Leonhard Hagen Berlin, DE 2 0
Yen, Hsin-Yung Oxford, GB 2 0

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