Multimodal chromatographic media for protein separation

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United States of America

PATENT NO 12134089
APP PUB NO 20190358621A1
SERIAL NO

16477752

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Abstract

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A chromatographic media for separating bio-polymers, the chromatographic media having cationic exchange properties and anionic exchange properties, the chromatographic media comprising: (a) non-porous substrate particles including an organic polymer, the substrate particles having a neutral hydrophilic layer at a surface of the non-porous substrate particles, in which the neutral hydrophilic layer is configured to reduce a binding of the bio-polymers directly to the non-porous substrate particles compared to a binding of the bio-polymer to the non-porous substrate particles without the neutral hydrophilic layer; (b) a charged first ion exchange layer bound to the substrate particles on top of the hydrophilic layer, the first ion exchange layer comprising first ion exchange groups; and (c) a charged second ion exchange layer bound to the substrate particles on top of the first ion exchange layer.

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Patent Owner(s)

Patent OwnerAddress
DIONEX CORPORATION445 LAKESIDE DRIVE SUNNYVALE CA 94085

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liehr, Shanhua Lin Palo Alto, US 3 1
Liu, Xiaodong Cupertino, US 213 1292
Pohl, Christopher A Union City, US 132 1325

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