Systems and methods for identifying HLA-associated tumor peptides

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12135327
APP PUB NO 20230417757A1
SERIAL NO

18343260

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Abstract

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Systems and methods for determining amino acid sequences of peptides that bind to MHC-I or HLA-I complex or MHC-II or HLA-II complex are provided. One embodiment includes isolating peptides from MHC or HLA class I or class II-peptide complexes and adding one or more known labeled peptides of interest to form a sample containing labeled peptides and unlabeled isolated peptides. The method also includes analyzing the sample with an LC-MS/MS system to obtain sequence data of the peptides, and increasing the sensitivity of the LC-MS/MS system when the labeled peptide is detected by the LC-MS/MS system. The method then concludes with determining the amino acid sequence of the unlabeled peptides in an m/z range that includes the m/z of the labeled peptide. The system can be triggered to increase the sensitivity in or near the m/z of the labeled peptide using an algorithm or computer program.

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Patent Owner(s)

Patent OwnerAddress
REGENERON PHARMACEUTICALS INC777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591-6707

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Salzler, Robert Tarrytown, US 4 1

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