Apparatus for efficient genetic modification of cells

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12139697
APP PUB NO 20230063282A1
SERIAL NO

17946948

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Abstract

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A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.

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Patent Owner(s)

Patent OwnerAddress
THE CHARLES STARK DRAPER LABORATORY INC555 TECHNOLOGY SQUARE CAMBRIDGE MA 02139

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Borenstein, Jeffrey T Holliston, US 102 2817
Kotz, Kenneth T Newton, US 25 138
Moore, Nathan Francis Canton, US 4 4
Tandon, Vishal Somerville, US 25 82
Teece, Bryan D Boston, US 4 9
Truslow, James Gillett Boston, US 3 1

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