Bacterial strain for releasing a recombinant protein in a fermentation method

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United States of America

PATENT NO 12139736
SERIAL NO

17258252

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A bacterial strain suitable for expressing recombinant proteins contains an open reading frame which codes for a recombinant protein, under control of a functional promoter. The bacterial strain contains an open reading frame which codes for a muted peptidologycan-associated lipoprotein (PAL protein), under control of a functional promoter, wherein the PAL protein is muted such that it contains no membrane anchor for the outer cell membrane of the bacterial strain. A plasmid codes for a recombinant protein. Fermentative production of recombinant protein is facilitated by using the bacterial strain, with increased product yields in the culture residue without leading to a substantial die-off of the bacterial cells.

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Patent Owner(s)

Patent OwnerAddress
WACKER CHEMIE AG81671 MÜNCHEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brunner, Markus Mering, DE 46 485
Koch, Johanna Munich, DE 5 5

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