System and method for characterizing protein dimerization

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United States of America

PATENT NO 12174173
APP PUB NO 20230110712A1
SERIAL NO

17979280

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Abstract

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Systems and methods to characterize dimerization interfaces at the subdomain level of a protein are provided. An exemplary method includes digesting a protein dimer sample into subdomains, labeling the digested protein sample, isolating labeled dimeric and monomeric subdomain fragments, and peptide mapping the labeled sample to determine where the dimer fragments are labeled and where the dimer fragments are not labeled. Regions that show decreased labeling extents in the dimer fraction than that in the monomer fraction are likely involved or in close proximity to the dimerization interface.

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Patent Owner(s)

Patent OwnerAddress
REGENERON PHARMACEUTICALS INC777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591-6707

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Wang, Shunhai Scarsdale, US 83 157
Yan, Yuetian Chappaqua, US 31 29

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