Methods for extracting proteins from a blood-based material

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United States of America

PATENT NO 12180250
APP PUB NO 20210261608A1
SERIAL NO

17320086

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Abstract

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Methods of producing multiple protein products from blood-based materials including alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins are described herein. The inventive methods include steps of: salt fractionation, chromatography, ultrafiltration, diafiltration, solvent-detergent treatment, and sterile filtration. Advantageously, the inventive methods are simple and produce alpha-1-proteinase inhibitor, gamma globulin, albumin, and other proteins in high yields. The sequence of process steps can be selected to obtain multiple products from various in-process materials, such as supernatants, pastes, chromatography flow-though, and chromatography washes.

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Patent Owner(s)

Patent OwnerAddress
PLASMA TECHNOLOGIES LLC36 N PRIOLEAU STREET CHARLESTON SC 29401

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Curtin, Dennis New York, US 20 59
Heldebrant, Charles Arcadia, US 5 8
Nowotnik, David Peter Colleyville, US 4 13
Zurlo, Eugene Charleston, US 16 15

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