2′-deoxy-2′,2′-difluorotetrahydrouridines with high purity and methods of making the same

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United States of America

PATENT NO 12187757
APP PUB NO 20220411457A1
SERIAL NO

17766074

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Abstract

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The invention relates to methods of synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.

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Patent Owner(s)

Patent OwnerAddress
TAIHO PHARMACEUTICAL CO LTDCHIYODA-KU TOKYO 101-8444

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Annaka, Kimiyoshi Osaka, JP 5 1
Davar, Nipun Pleasanton, US 37 302
Matsui, Motoshi Osaka, JP 11 0
Miyake, Masahiro Osaka, JP 41 340
Scott, Ian Niwot, US 34 873
Zuend, Gemma Haywood, US 2 0

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