Synthetic combinatorial AAV3 capsid library

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12188037
APP PUB NO 20200181644A1
SERIAL NO

15769615

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Abstract

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Compositions and methods for producing modified AAV Cap genes and combinatorial libraries of chimeric AAV vectors and virions in an AAV serotype 3 background. Selecting for modified AAV3 virions displaying cell- or tissue-specific tropisms differing from WT AAV3. Using the synthetic combinatorial AAV3 capsid libraries for introducing into a selected target host cells one or more nucleic acid molecules useful in diagnostic and/or therapeutic gene-therapy regimens.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATED223 GRINTER HALL GAINESVILLE FL 32611

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Marsic, Damien Rockville, US 8 69
Zolotukhin, Sergei Gainesville, US 53 1558

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