Multivalent malaria transmission-blocking vaccines

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United States of America Patent

PATENT NO 12202865
SERIAL NO

17601056

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Abstract

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The present invention relates to a method for recombinant production of a fusion protein comprising multiple malaria antigens for inducing immune responses comprising a combination of antibodies. In particular, the fusion proteins of the present invention comprise fragments of both Pfs230 and Pfs48/45 to lower the required threshold of functional antibodies and to reduce the risk of escape mutations. Thus, the fusion proteins of the present invention are suitable for use in a multivalent malaria vaccine.

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Patent OwnerAddress
STATENS SERUM INSTITUTDK-2300 COPENHAGEN S

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Singh, Susheel Kumar Vanlose, DK 2 0
Theisen, Michael Holte, DK 11 46

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