Binder selection using capillary electrophoresis

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United States of America Patent

PATENT NO 12203130
APP PUB NO 20220042079A1
SERIAL NO

17416063

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Abstract

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A method of capillary electrophoresis is provided for binder selection. In an embodiment, a capillary electrophoresis method comprises selecting an electroosmotic flow (EOF) in a capillary such that at least one target-binder (TB) complex has a target-binder velocity vector (vTB) co-directed with an electric field vector (E) and at least one non-binder (N) has a non-binder velocity vector (vN) in the opposite direction to the electric field vector (E); introducing a sample comprising the at least one target-binder (TB) complex, the at least one non-binder (N), and at least one running buffer into a capillary inlet of the capillary; applying an electric field directed from the capillary inlet to a capillary outlet of the capillary to separate the at least one target-binder (TB) complex from the at least one non-binder (N); and detecting the at least one target-binder complex.

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Patent Owner(s)

Patent OwnerAddress
KRYLOV SERGEY NTORONTO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Krylov, Sergey N Toronto, CA 4 32

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