Gene chip and method of preparing the same

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United States of America

PATENT NO 12208365
APP PUB NO 20210162365A1
SERIAL NO

17266994

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Abstract

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A gene chip includes a chip carrier, a plurality of DNA nanoballs assembled on the chip carrier, and a polymer film formed on the chip carrier and wrapping the DNA nanoballs. The polymer film includes at least one of a film of a positively charged polymer, a film of a positively charged polymer which is modified, a film of a zwitterionic polymer, and a composite polymer film. The composite polymer film is formed by a layer-by-layer self-assembly process of a positively charged polymer and a negatively charged polymer. The gene chip has good sequencing quality and different functions can be achieved by coating with different polymers, such as the chip surface rapidly drying out and surface non-specific adsorption. A method of preparing a gene chip is further disclosed.

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Patent Owner(s)

Patent OwnerAddress
BGI SHENZHENMAIN BUILDING BEISHAN INDUSTRIAL ZONE YANTIAN STREET YANTIAN DISTRICT SHENZHEN 518083

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gong, Mei-Hua Shenzhen, CN 1 0
Jiang, Xue-Qin Shenzhen, CN 1 0
Li, Han-Dong Shenzhen, CN 1 0
Li, Yuan Shenzhen, CN 465 4935
Luo, Yin-Ling Shenzhen, CN 1 0
Shafto, Jay Willis Shenzhen, CN 3 13
Wang, Hui Shenzhen, CN 1115 8921
Wang, Zhao-Hui Shenzhen, CN 4 51
Xing, Cheng-Mei Shenzhen, CN 1 0
Yang, Jin Shenzhen, CN 531 3726
Zhang, Wen-Wei Shenzhen, CN 6 0
Zhang, Zhen-Hua Shenzhen, CN 4 3

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