Cell for use in enzyme assays

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United States of America

PATENT NO 12209269
APP PUB NO 20240117408A1
SERIAL NO

18199056

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Abstract

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Cells are described that are useful in rapid, sensitive, and accurate cell-based assays for enzyme activity, particularly for enzyme activities associated with botulinum toxins. Such cell expresses a construct that includes an anchor region, a cleavage site, and a reporting region having two or more identical reporter peptides. Enzymatic activity at the cleavage site releases the reporter region into the cytosol of the cell, where multiple degradation events occur. The observed change in the signal is proportional to the enzymatic activity.

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Patent Owner(s)

Patent OwnerAddress
BIOMADISON INC1568 LUNETA DRIVE DEL MAR CA 92014

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Tucker, Ward C Monona, US 29 120

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