kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12221641
APP PUB NO 20210371892A1
SERIAL NO

17285888

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Abstract

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Provided herein are compositions and methods for improved production of steviol glycosides in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a Stevia rebaudiana kaurenoic acid hydroxylase. In some embodiments, the host cell further comprises one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing one or more steviol glycosides in the host cell. The compositions and methods described herein provide an efficient route for the heterologous production of steviol glycosides, including but not limited to, rebaudioside D and rebaudioside M.

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Patent Owner(s)

Patent OwnerAddress
AMYRIS INC5885 HOLLIS STREET SUITE 100 EMERYVILLE CA 94608

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Borisova, Svetlana Alekseyevna Emeryville, US 1 0
Garcia, De Gonzalo Chantal V Emeryville, US 1 0
Jackson, Shaina J Emeryville, US 1 0
Li, Wenzong Emeryville, US 5 2
Lund, Sean Emeryville, US 5 0
Warbington, Hailley Emeryville, US 1 0
Wichmann, Gale A Emeryville, US 2 0
Xiong, Yi Emeryville, US 54 440

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