Process for the preparation of 2,2′,2″-(10-((2R,3S)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes

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United States of America

PATENT NO 12227527
APP PUB NO 20210284662A1
SERIAL NO

17258890

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Abstract

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The present invention relates to an improved process for the preparation of 2,2′,2″-(10-((2R,3S)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid, gadolinium (III) with iron metal content less than 5 ppm and free gadolinium content less than 10 ppm, which is represented by the formula (1). The present invention further relates to an improved process for the preparation of calcium complex of 10-(2,3-Dihydroxy-1-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclo decane-1,4,7-triacetic acid known as Calcobutrol (1a) and its sodium salt of formula (1b) with purity greater than 98.0%.

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Patent Owner(s)

  • BIOPHORE INDIA PHARMACEUTICALS PVT LTD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Pitta, Bhaskar Reddy Hyderabad, IN 16 9
Pullagurla, Manik Reddy Hyderabad, IN 39 20
Rangisetty, Jagadeesh Babu Hyderabad, IN 42 46

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