Method for preparing nicotinamide mononucleotide by using nicotinamide as raw material

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United States of America

PATENT NO 12227534
APP PUB NO 20220363704A1
SERIAL NO

17623989

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Abstract

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The invention relates to a method for preparing nicotinamide mononucleotide by using nicotinamide as a raw material, which comprises: in acetonitrile, dichloromethane, 1,2-dichloroethane or liquid sulfur dioxide as a solvent, allowing nicotinamide and tetraacetyl ribose to react as catalyzed by trimethylsilyl trifluoromethanesulfonate or tin tetrachloride, adjusting a pH value thereof to 3-5, adding a sodium methoxide solution thereto to react at −15° C. to 5° C., adjusting a pH value thereof to 3-5, and subjecting the reaction mixture to microfiltration and nanofiltration using a membrane concentrator, thereby obtain a nicotinamide ribose solution; allowing the nicotinamide ribose solution to react as catalyzed by nicotinamide ribokinase in the presence of Mg ions, ATP and a buffer, thereby obtaining nicotinamide mononucleotide. The method of the invention omits the step of refining nicotinamide ribose, and thus has simpler process, lower cost and less time consumption, and has the advantages of faster reaction speed and lower enzyme consumption compared with the enzyme catalytic process directly using refined nicotinamide ribose solid.

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Patent Owner(s)

  • BONTAC BIO-ENGINEERING (SHENZHEN) CO., LTD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Wang, Qin Shenzhen, CN 181 661
Xu, Haojie Shenzhen, CN 14 52
Zhang, Guiping Shenzhen, CN 16 61
Zhang, Qi Shenzhen, CN 768 6016
Zhang, Zhang Shenzhen, CN 221 2480

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