Triterpene saponins, methods of synthesis and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12227535
APP PUB NO 20230131867A1
SERIAL NO

17947716

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Abstract

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The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

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Patent Owner(s)

  • SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adams, Michelle Waterville, US 6 37
Chea, Eric Flushing, US 8 25
Deng, Kai Guilderland, US 35 71
Fernandez-Tejada, Alberto New York, US 13 29
Gardner, Jeffrey New York, US 25 179
Gin, David New York, US 7 77
Livingston, Philip New York, US 16 80
Nordstroem, Lars Ulrik New York, US 3 12
Ragupathi, Govindaswami New York, US 22 232
Tan, Derek New York, US 10 25
Walkowicz, William Brooklyn, US 5 12

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