Cancer detection and classification using methylome analysis

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12227737
APP PUB NO 20230203473A1
SERIAL NO

18061273

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Abstract

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There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.

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Patent Owner(s)

  • UNIVERSITY HEALTH NETWORK; SINAI HEALTH SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bratman, Scott Victor Toronto, CA 7 11
Diniz, De Carvalho Daniel Toronto, CA 11 11
Ravinarayana, Chakravarthy Ankur Toronto, CA 4 7
Shen, Shu Yi Markham, CA 9 21
Singhania, Rajat Toronto, CA 9 21

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