Compositions and methods for immune repertoire sequencing

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12227878
APP PUB NO 20210285027A1
SERIAL NO

17302638

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire using genomic DNA from a biological sample. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Nucleic acid sequences of variable regions associated with the immune cell receptor are determined to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.

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Patent Owner(s)

  • LIFE TECHNOLOGIES CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lin, Lifeng Dublin, US 33 46
Linch, Elizabeth Menifee, US 2 1
Looney, Timothy Austin, US 30 33
Lowman, Geoffrey Carlsbad, US 10 5
Miller, Lauren San Diego, US 18 65

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