Scaffolded nucleic acid polymer particles and methods of making and using

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12234452
APP PUB NO 20200239877A1
SERIAL NO

16841546

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Abstract

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The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.

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Patent Owner(s)

  • LIFE TECHNOLOGIES CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hinz, Wolfgang Carlsbad, US 178 16334
Leamon, John Stonington, US 46 1884
Light, David Branford, US 91 1509
Rothberg, Jonathan M Guilford, US 567 39206

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