Biodegradable lipids for the delivery of active agents

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12239709
APP PUB NO 20240285767A1
SERIAL NO

18589636

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Abstract

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The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

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Patent Owner(s)

  • ALNYLAM PHARMACEUTICALS INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Akinc, Akin Cambridge, US 113 3427
Baillie, Thomas A Cambridge, US 8 233
Jayaraman, Muthusamy Cambridge, US 107 3970
Kandasamy, Pachamuthu Cambridge, US 48 140
Maier, Martin Cambridge, US 260 4382
Manoharan, Muthiah Cambridge, US 491 18658
Matsuda, Shigeo Cambridge, US 47 578
Nair, Jayaprakash K Cambridge, US 63 214
Rajeev, Kallanthottathil G Cambridge, US 260 8660

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