Composition comprising aflibercept and a variant thereof, and related methods and uses

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United States of America

PATENT NO 12240888
SERIAL NO

18679192

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Abstract

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Provided is a composition comprising aflibercept and a variant thereof, wherein the variant is a truncation variant with a truncated VEGF binding portion of aflibercept, and wherein the content of the truncation variant is less than or equal to about 20% by mass percentage. Also provided is a pharmaceutical formulation comprising the composition. Further, provided are a method for detecting the variant and use of the variant in quality inspection or quality control of an aflibercept-containing product.

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Patent Owner(s)

Patent OwnerAddress
QILU PHARMACEUTICAL CO LTDNO 317 XINLUO STREET HIGH TECHNICAL ZONE JINAN SHANDONG 250100

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
An, Zhenming Shandong, CN 2 0
Li, Daoyuan Shandong, CN 5 80
Liu, Chuanlei Shandong, CN 1 0
Liu, Feifei Shandong, CN 11 12
Wan, Peng Shandong, CN 41 55
Wang, Guijiang Shandong, CN 2 0
Wang, Jiulin Shandong, CN 7 95
Wang, Qingmin Shandong, CN 6 2
Xie, Bo Shandong, CN 80 1871
Yu, Yue Shandong, CN 280 2832
Zheng, Huanlan Shandong, CN 1 0

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