CAR library and scFv manufacturing method

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12241061
APP PUB NO 20220290128A1
SERIAL NO

17428214

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Abstract

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Provided are a CAR library used to screen scFvs that can be functional in CAR-T cells, and an scFv manufacturing method in which the CAR library is used. A chimeric antigen receptor (CAR) library of the present invention includes nucleic acids coding for first CARs. Each of the first CARs includes a first antigen-binding domain, a first transmembrane domain, and a first intracellular signaling domain. The first antigen-binding domain includes a first single-chain antibody (scFv) to be screened for the ability to bind to a target antigen. The first scFv includes a first heavy-chain variable region and a first light-chain variable region. The first heavy-chain variable region and the first light-chain variable region meet a predetermined condition.

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Patent Owner(s)

  • NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fujiwara, Hiroshi Ehime, JP 157 1919
Ochi, Toshiki Ehime, JP 3 3
Takenaka, Katsuto Ehime, JP 4 36
Yasukawa, Masaki Ehime, JP 7 15

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