Methods for generating barcoded nucleic acid molecules using fixed cells

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12241890
APP PUB NO 20210190770A1
SERIAL NO

17131174

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Abstract

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The present disclosure provides compositions and methods for using fixed biological samples in partition-based assays. In at least one embodiment, the disclosure provides a composition comprising a fixed biological sample and an un-fixing agent contained in a partition, such as a discrete droplet. In some embodiments, the disclosure provides un-fixing agent compounds capable of catalytically cleaving crosslinks in fixed biological samples, particularly crosslinked nucleic acids, such as RNA.

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Patent Owner(s)

  • 10X GENOMICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Delaney, Joshua Oakland, US 19 847
Gohil, Shalini Castro Valley, US 19 638
Herschleb, Jill San Francisco, US 5 151
Kim, Albert Los Angeles, US 61 1178
Lowe, Adam Mountain House, US 85 1638
Tjandra, Meiliana Dublin, US 18 282

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