Nanoparticle vaccine adjuvant and methods of use thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12246097
APP PUB NO 20230157967A1
SERIAL NO

18151182

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Abstract

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Non-liposome, non-micelle particles formed of a lipid, an additional adjuvant such as a TLR4 agonist, a sterol, and a saponin are provided. The particles are porous, cage-like nanoparticles, also referred to as nanocages, and are typically between about 30 nm and about 60 nm. In some embodiments, the nanocages include or are administered in combination with an antigen. The particles can increase immune responses and are particularly useful as adjuvants in vaccine applications and related methods of treatment. Preferred lipids, additional adjuvants including TLR4 agonists, sterols, and saponins, methods of making the nanocages, and method of using them are also provided.

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Patent Owner(s)

  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY; LA JOLLA INSTITUTE FOR IMMUNOLOGY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crotty, Shane San Diego, US 12 59
Irvine, Darrell J Arlington, US 89 1087
Kato, Yu San Diego, US 35 47
Silva, Murillo Lancaster, US 3 0

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