Enzymatic circuits for molecular sensors

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12247251
APP PUB NO 20220002777A1
SERIAL NO

17138314

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Abstract

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In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.

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  • SEMICON BIO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alagarswamy, Govindaraj Venkatesh San Diego, US 2 1
Geiser, Tim San Diego, US 37 480
Merriman, Barry L La Jolla, US 30 646
Mola, Paul San Diego, US 33 459

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