Combinatorial barcode sequences, and related systems and methods

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12264363
APP PUB NO 20220213544A1
SERIAL NO

17546151

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Abstract

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A system for nucleic acid sequencing is provided. The system comprises a sequencing device configured to expose a tagged polynucleotide comprising a combinatorial barcode sequence and a sample polynucleotide to sequential nucleotide flows, each flow comprising one species of nucleotide and the sequential flows being in a predetermined order based on the species of nucleotide such that exposing of the tagged polynucleotide to the sequential nucleotide flows causes incorporations of nucleotides from the sequential nucleotide flows into the tagged polynucleotide over the barcode sequence The sequencing device is configured to detect a series of signals over the barcode sequence resulting from the incorporations, wherein the predetermined order of nucleotide flows comprises a repetition of a flow order motif that is based on a sequence motif. The system comprises a computing device configured to resolve the detected series of signals to determine the combinatorial barcode sequence.

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Patent Owner(s)

Patent OwnerAddress
LIFE TECHNOLOGIES CORPORATION5823 NEWTON DRIVE CARLSBAD CA 92008

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hubbell, Earl Palo Alto, US 76 993

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