US Patent Application No: 2001/0001,663

Number of patents in Portfolio can not be more than 2000

Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component

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Abstract

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There is provided a synovial cell growth inhibitor, or a pharmaceutical composition for treatment of chronic rheumatoid arthritis based on the synovial cell growth inhibitor. The pharmaceutical composition for treatment of chronic rheumatoid arthritis or synovial cell growth inhibitor contains an IL-6 antagonist, such as IL-6 antibody or IL-6R antibody, as an effective component.

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International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kishimoto, Tadamitsu Osaka, JP 46 879
Mihara, Masahiko Gotenba-shi, JP 12 308
Moriya, Yoichiro Gotenba-shi, JP 3 167
Oshugi, Yosiyuki Gotenba-shi, JP 1 48

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 5,670,373 Antibody to human interleukin-6 receptor 70 1994
* 2003/0236,260 Use of EP4 receptor ligands in the treatment of IL-6 involved diseases 1 2003
 
Tadamitsu Kishimoto (1)
* 6,723,319 Method of treating inflammatory intestinal diseases containing as the ingredient IL-6 receptors antibodies 63 2000
 
CHUGAI SEIYAKU KABUSHIKI KAISHA (3)
* 2002/0187,150 Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient 23 2002
* 2004/0115,197 Remedies for infant chronic arthritis-relating diseases 39 2003
* 2006/0292,147 Blood MMP-3 level-lowering agent comprising IL-6 antagonist as active ingredient 59 2006
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
KEIO UNIVERSITY (2)
8,771,686 Methods for treating a disease involving choroidal neovascularization by administering an IL-6 receptor antibody 4 2007
* 2010/0034,811 THERAPEUTIC AGENTS FOR DISEASES INVOLVING CHOROIDAL NEOVASCULARIZATION 12 2007
 
ALDERBIO HOLDINGS LLC (29)
7,935,340 Antibodies to IL-6 and use thereof 16 2008
* 2010/0290,993 Antibodies to IL-6 and use thereof 15 2008
* 2009/0104,187 Novel Rabbit Antibody Humanization Methods and Humanized Rabbit Antibodies 21 2008
* 2009/0028,784 Antibodies to IL-6 and use thereof 20 2008
8,404,235 Antagonists of IL-6 to raise albumin and/or lower CRP 1 2008
8,252,286 Antagonists of IL-6 to prevent or treat thrombosis 15 2008
7,906,117 Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever 15 2008
* 2009/0291,089 Antagonists of IL-6 to prevent or treat Thrombosis 15 2008
* 2009/0291,082 Antagonists of IL-6 to raise Albumin and/or lower CRP 15 2008
8,062,864 Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies 15 2009
* 2009/0297,436 ANTIBODIES TO IL-6 AND USE THEREOF 21 2009
* 2009/0297,513 ANTIBODIES TO IL-6 AND USE THEREOF 19 2009
8,323,649 Antibodies to IL-6 and use thereof 16 2009
9,452,227 Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments 0 2009
8,900,580 Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments 0 2009
* 2010/0150,829 Antibodies to IL-6 and use thereof 24 2009
9,468,676 Antagonists of IL-6 to prevent or treat thrombosis 0 2010
8,992,904 Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity 0 2010
8,535,671 Methods of reducing CRP and/or increasing serum albumin in patients in need using IL-6 antibodies of defined epitopic specificity 0 2011
9,304,134 Anti-IL-6 antibodies for the treatment of anemia 0 2011
9,274,115 Anti-IL-6 antibodies for the treatment of anemia 0 2011
8,992,908 Anti-IL-6 antibodies for the treatment of oral mucositis 0 2011
8,992,920 Anti-IL-6 antibodies for the treatment of arthritis 0 2011
8,999,330 Antagonists of IL-6 to prevent or treat thrombosis 0 2012
9,212,223 Antagonists of IL-6 to prevent or treat thrombosis 0 2012
9,187,560 Antagonists of IL-6 to treat cachexia, weakness, fatigue, and/or fever 0 2012
9,085,615 Antibodies to IL-6 to inhibit or treat inflammation 0 2012
9,265,825 Antagonists of IL-6 to raise albumin and/or lower CRP 0 2013
9,241,990 Antagonists of IL-6 to raise albumin and/or lower CRIP 0 2013
 
KYMAB LIMITED (1)
9,017,678 Method of treating rheumatoid arthritis using antibody to IL6R 0 2014
 
ORTHO BIOTECH INC. (7)
7,560,112 Anti-il-6 antibodies, compositions, methods and uses 32 2006
* 2006/0257,407 Anti-IL-6 antibodies, compositions, methods and uses 35 2006
7,833,755 Anti-IL-6 antibody nucleic acid molecules and methods 14 2009
8,067,003 Methods of treating conditions using anti-IL-6 antibodies 14 2010
* 2011/0081,355 Methods of Diagnosing and Treating Conditions Using Anti-IL-6 Antibodies 0 2010
RE43672 Anti-IL-6 antibodies, compositions, methods and uses 14 2011
8,226,611 Anti-IL-6 antibodies, compositions, methods and uses 20 2011
 
OSAKA UNIVERSITY (2)
9,260,516 Method for promoting muscle regeneration by administering an antibody to the IL-6 receptor 0 2007
* 2010/0008,907 MUSCLE REGENERATION PROMOTER 21 2007
 
NATIONAL HOSPITAL ORGANIZATION (2)
8,623,355 Methods for suppressing acute rejection of a heart transplant 5 2006
* 2009/0263,384 Agents for Suppressing the Induction of Cytotoxic T Cells 15 2006
 
PENTRACOR GMBH (1)
* 2007/0036,788 Use of a compound for reducing the biological effectiveness of il-6 32 2004
 
CHUGAI SEIYAKU KABUSHIKI KAISHA (17)
* 2010/0015,133 Methods for Producing Polypeptides by Regulating Polypeptide Association 30 2006
8,470,316 Agents for suppressing damage to transplanted islets after islet transplantation 7 2006
* 2009/0220,499 Agents for Suppressing Damage to Transplanted Islets After Islet Transplantation 12 2006
8,945,558 Methods for treating myocardial infarction comprising administering an IL-6 inhibitor 0 2006
* 2009/0220,500 AGENTS FOR TREATING CARDIOPATHY 13 2006
* 2009/0269,335 THERAPEUTIC AGENT FOR PROSTATE CANCER 17 2006
9,096,651 Method of modifying isoelectric point of antibody via amino acid substitution in CDR 4 2008
* 2011/0076,275 Method of Modifying Isoelectric Point of Antibody Via Amino Acid Substitution in CDR 17 2008
* 2010/0298,542 Modified Antibody Constant Region 18 2008
* 2011/0111,406 ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO TWO OR MORE ANTIGEN MOLECULES REPEATEDLY 27 2009
8,562,991 Antibody molecules that bind to IL-6 receptor 4 2009
* 2011/0098,450 Antibody Molecules 13 2009
8,575,317 Anti-NR10 antibody and use thereof 4 2009
9,228,017 Antibody constant region variant 2 2010
9,340,615 Anti-AXL antibody 0 2010
8,623,360 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly 0 2012
9,399,680 Nucleic acids encoding anti-NR10 antibodies 0 2013
 
PFIZER INC. (4)
8,188,235 Antibodies to IL-6 and their uses 0 2009
* 2009/0317,402 ANTIBODIES TO IL-6 AND THEIR USES 5 2009
8,436,158 Antibodies to IL-6 and their uses 0 2012
8,846,037 Antibodies to IL-6 and their uses 0 2013
 
NATIONAL CANCER CENTER (1)
* 2011/0150,869 Neuroinvasion Inhibitor 14 2009
 
Alderbio Holdings Inc. (1)
8,178,101 Use of anti-IL-6 antibodies having specific binding properties to treat cachexia 15 2009
 
HOFFMANN-LA ROCHE INC. (1)
8,580,264 Subcutaneously administered anti-IL-6 receptor antibody 2 2011
 
JANSSEN BIOTECH, INC. (2)
8,623,362 Anti-IL-6 antibodies 14 2012
9,340,613 Anti-IL-6 antibodies, compositions, methods and uses 0 2013
 
MEDIMMUNE LIMITED (2)
8,198,414 Anti-human IL-6 antibodies 0 2007
9,005,620 Compounds 0 2012
* Cited By Examiner