US Patent Application No: 2001/0001,663

Number of patents in Portfolio can not be more than 2000

Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component

ALSO PUBLISHED AS: 8017121
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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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There is provided a synovial cell growth inhibitor, or a pharmaceutical composition for treatment of chronic rheumatoid arthritis based on the synovial cell growth inhibitor. The pharmaceutical composition for treatment of chronic rheumatoid arthritis or synovial cell growth inhibitor contains an IL-6 antagonist, such as IL-6 antibody or IL-6R antibody, as an effective component.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kishimoto, Tadamitsu Osaka, JP 46 532
Mihara, Masahiko Gotenba-shi, JP 12 154
Moriya, Yoichiro Gotenba-shi, JP 3 86

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 5,670,373 Antibody to human interleukin-6 receptor 51 1994
* 2003/0236,260 Use of EP4 receptor ligands in the treatment of IL-6 involved diseases 0 2003
 
Tadamitsu Kishimoto (1)
* 6,723,319 Method of treating inflammatory intestinal diseases containing as the ingredient IL-6 receptors antibodies 45 2000
 
CHUGAI SEIYAKU KABUSHIKI KAISHA (3)
* 2002/0187,150 Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient 17 2002
* 2004/0115,197 Remedies for infant chronic arthritis-relating diseases 30 2003
* 2006/0292,147 Blood MMP-3 level-lowering agent comprising IL-6 antagonist as active ingredient 43 2006
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Alderbio Holdings Inc. (1)
8,178,101 Use of anti-IL-6 antibodies having specific binding properties to treat cachexia 7 2009
 
KEIO UNIVERSITY (1)
8,771,686 Methods for treating a disease involving choroidal neovascularization by administering an IL-6 receptor antibody 2 2007
 
HOFFMANN-LA ROCHE INC. (1)
8,580,264 Subcutaneously administered anti-IL-6 receptor antibody 1 2011
 
ALDERBIO HOLDINGS LLC (13)
7,935,340 Antibodies to IL-6 and use thereof 8 2008
8,404,235 Antagonists of IL-6 to raise albumin and/or lower CRP 1 2008
8,252,286 Antagonists of IL-6 to prevent or treat thrombosis 7 2008
7,906,117 Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever 7 2008
8,062,864 Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies 7 2009
8,323,649 Antibodies to IL-6 and use thereof 7 2009
8,900,580 Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments 0 2009
8,992,904 Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity 0 2010
8,535,671 Methods of reducing CRP and/or increasing serum albumin in patients in need using IL-6 antibodies of defined epitopic specificity 0 2011
8,992,908 Anti-IL-6 antibodies for the treatment of oral mucositis 0 2011
8,992,920 Anti-IL-6 antibodies for the treatment of arthritis 0 2011
8,999,330 Antagonists of IL-6 to prevent or treat thrombosis 0 2012
9,085,615 Antibodies to IL-6 to inhibit or treat inflammation 0 2012
 
ORTHO BIOTECH, INC. (5)
7,560,112 Anti-il-6 antibodies, compositions, methods and uses 21 2006
7,833,755 Anti-IL-6 antibody nucleic acid molecules and methods 6 2009
8,067,003 Methods of treating conditions using anti-IL-6 antibodies 6 2010
RE43672 Anti-IL-6 antibodies, compositions, methods and uses 6 2011
8,226,611 Anti-IL-6 antibodies, compositions, methods and uses 11 2011
 
Kymab Limited (1)
9,017,678 Method of treating rheumatoid arthritis using antibody to IL6R 0 2014
 
JANSSEN BIOTECH, INC. (1)
8,623,362 Anti-IL-6 antibodies 6 2012
 
NATIONAL HOSPITAL ORGANIZATION (1)
8,623,355 Methods for suppressing acute rejection of a heart transplant 3 2006
 
PFIZER INC (3)
8,188,235 Antibodies to IL-6 and their uses 0 2009
8,436,158 Antibodies to IL-6 and their uses 0 2012
8,846,037 Antibodies to IL-6 and their uses 0 2013
 
MEDIMMUNE LIMITED (2)
8,198,414 Anti-human IL-6 antibodies 0 2007
9,005,620 Compounds 0 2012
 
CHUGAI SEIYAKU KABUSHIKI KAISHA (6)
8,470,316 Agents for suppressing damage to transplanted islets after islet transplantation 5 2006
8,945,558 Methods for treating myocardial infarction comprising administering an IL-6 inhibitor 0 2006
9,096,651 Method of modifying isoelectric point of antibody via amino acid substitution in CDR 0 2008
8,562,991 Antibody molecules that bind to IL-6 receptor 2 2009
8,575,317 Anti-NR10 antibody and use thereof 2 2009
8,623,360 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly 0 2012
* Cited By Examiner