Methods for enhancing the production of viral vaccines in cell culture
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United States of America Patent
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Feb 3, 2004
Grant Date -
May 24, 2001
app pub date -
Dec 13, 2000
filing date -
Aug 22, 1995
priority date (Note) -
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Abstract
Methods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.
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