Method of providing sustained analgesia with buprenorphine
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United States of America Patent
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Feb 5, 2002
Grant Date -
May 31, 2001
app pub date -
Jan 8, 2001
filing date -
Feb 24, 1997
priority date (Note) -
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Abstract
A method of effectively treating pain in humans is achieved by administering buprenorphinein accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of buprenorphine for at least an additional two-day dosing interval in accordance with substantially zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing interval.
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