Patterned binding of functionalized microspheres for optical diffraction-based biosensors
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United States of America Patent
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Jun 3, 2003
Grant Date -
Jun 21, 2001
app pub date -
Dec 8, 2000
filing date -
Dec 11, 1998
priority date (Note) -
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Abstract
The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capable of binding with a target analyte. Additionally, the system comprises a polymer film, which may include a metal coating, upon which is printed a specific, predetermined pattern of a analyte-specific receptors. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
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