Method for establishing a dosage plan for thrombin inhibitors
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United States of America Patent
Stats
-
Dec 3, 2002
Grant Date -
Jul 5, 2001
app pub date -
Nov 12, 1998
filing date -
Dec 15, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
After a standard dose of a hirudin or an oral thrombin inhibitor is given to a recipient, the concentration of the hirudin or oral thrombin inhibitor in the blood of the recipient is determined using the ecarin clogging time test. From the ratio of the dose given to the recipient to the measured ecarin clotting time, a dosage plan-i.e., the dosage of the hirudin or oral thrombin inhibitor to be given thereafter-is established. For this purpose a pharmacokinetics/pharmacodynamics model is employed using a statistics program. A further dose of the hirudin or oral thrombin inhibitor is then administered to the recipient in accordance with the established dosage plan.
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