Variant human .alpha.7 acetylcholine receptor subunit, and methods of production and uses thereof
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United States of America Patent
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Nov 27, 2001
Grant Date -
Jul 5, 2001
app pub date -
Dec 20, 1996
filing date -
Dec 20, 1996
priority date (Note) -
Expired
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Abstract
A variant human .alpha.7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human .alpha.7 nAChR. Nucleic acid molecules encoding the variant human .alpha.7 nAChR, receptors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
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