COMPOSTIION, METHOD AND SYSTEM FOR IDENTIFYING NOVEL ANTIMICROBIAL AGENTS
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United States of America Patent
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Issued Date -
Jul 5, 2001
app pub date -
Sep 25, 1998
filing date -
Sep 25, 1998
priority date (Note) -
Abandoned
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Abstract
An composition, method and system for identifying novel antimicrobial agents including the steps of, displaying a .beta.-lactamase inhibitor protein on a virus, contacting the virus with a .beta.-lactamase binding protein target, selecting for the virus that has a higher affinity for the target and testing the .beta.-lactamase inhibitor protein for antimicrobial activity, is disclosed. The invention also includes a nucleic acid encoding a fusion protein comprising a .beta.-lactamase inhibitor protein and an affinity carrier and the protein expressed therefrom. Mutant .beta.-lactamase inhibitor proteins may be produced, characterized, isolated and expressed in prokaryotic cells and used as antimicrobial agents.
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