ANTIBODIES THAT BIND TO THE NIDOGEN-BINDING DOMAIN OF LAMININ, THEIR PRODUCTION AND USE
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United States of America Patent
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N/A
Issued Date -
Jul 5, 2001
app pub date -
Jul 15, 1999
filing date -
Jan 17, 1997
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention relates to monoclonal and polyclonal antibodies, and their parts, which bind specifically to the nidogen-binding domain of laminin, to processes for their preparation and to their use as pharmaceuticals, as diagnostic agents for detecting laminin isoforms and as model substances for developing and evaluating substances which affect the nidogen/laminin interaction. The antibodies according to the invention, or their parts, bind preferentially to the laminin .gamma.1 III 4 domain, in particular in the highly conserved region of the a and c loops, and are able to inhibit the association of laminin and nidogen.
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