Diltiazem controlled release formulation and method of manufacture
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United States of America Patent
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Feb 25, 2003
Grant Date -
Jul 12, 2001
app pub date -
Jul 20, 1998
filing date -
Jul 20, 1998
priority date (Note) -
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Abstract
A controlled release diltiazem dosage formulation comprising a plurality of active pellets coated with an extended release coating wherein the active pellets contain diltiazem or a pharmaceutically acceptable salt, a pharmaceutically acceptable inert seed and a binder and the extended release coating contains a water insoluble water permeable polymer, a channeling agent, a lubricant and optionally a surfactant. A single batch intermittent method of manufacturing a heterogeneous population of extended release pellets for use as a dosage formulation is also disclosed.
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