Huntingtin-related therapeutics and bioassay
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United States of America Patent
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Aug 5, 2003
Grant Date -
Jul 12, 2001
app pub date -
Nov 14, 1997
filing date -
Nov 15, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method of identifying a compound useful in the treatment of a disease characterized by the presence of mutant huntingtin by: (a) providing a cell which expresses mutant huntingtin; (b) contacting the cell with a test compound; and (c) determining whether the level of clathrin-mediated endocytosis is increased in the presence of the test compound, compared to the level in the absence of the test compound. An increase in clathrin-mediated endocytosis is an indication that the test compound is useful in treating the disease.
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