Treatment of multiple sclerosis using COP-1 and Th2-enhancing cytokines
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United States of America Patent
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Issued Date -
Jul 12, 2001
app pub date -
Feb 6, 2001
filing date -
Feb 13, 1998
priority date (Note) -
Abandoned
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Abstract
The invention relates to a treatment for multiple sclerosis. COP-1 (copolymer-1), a synthetic polymer consisting of a mixture of random synthetic polypeptides composed of L-alanine, L-glutamic acid, L-lysine and L-tyrosine in a molar ratio of about 6:2:5:1, is administered mucosally to patients afflicted with the disease in combination with Th2 enhancing cytokines such as IL-4 or IL-10. The combination treatment of IL-4 or IL-10 (preferably orally administered) with mucosally administered COP-1 shows a substantially greater suppressive effect than does treatment with cytokine or COP-1 alone.
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