Nitrile derivatives that inhibit cathepsin K
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United States of America Patent
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-
Mar 11, 2003
Grant Date -
Jul 19, 2001
app pub date -
Dec 21, 2000
filing date -
Dec 24, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds of the formula: ##STR1## wherein R.sup.1 to R.sup.7 and Y are as defined in the specification, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof, are useful for treating diseases associated with cystein proteases, such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.
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