Reagents useful for detecting diseases of the gastrointestinal tract
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United States of America Patent
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Sep 30, 2003
Grant Date -
Aug 2, 2001
app pub date -
Mar 30, 1998
filing date -
Mar 31, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS 198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS 198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS 198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
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