Treating pulmonary disorders with gaseous agent causing repletion of GSNO
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United States of America Patent
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May 16, 2006
Issued Date -
N/A
app pub date -
Feb 14, 2001
filing date -
Sep 8, 1999
priority date (Note) -
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Abstract
Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas, agent causing repletion or increase of the GSNO pool or protection against toxicity and does so independently of reaction with oxygen. Agents include ethyl nitrite, NOCl, NOBr, NOF, NOCN, N.sub.2O.sub.3, HNO, and H.sub.2S. Optionally, N-acetylcysteine, ascorbate, H.sub.2S or HNO is administered in addition to other GSNO repleting agent to potentiate the effect of said agent.
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