Pyridazine derivatives, manufacturing method and related composition
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United States of America Patent
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May 28, 2002
Grant Date -
Aug 9, 2001
app pub date -
Dec 15, 2000
filing date -
Dec 15, 1999
priority date (Note) -
In Force
status (Latency Note)
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Abstract
Ultraviolet absorbents and photostabilizers have an excellent absorption ability in a wide range of ultraviolet rays, and also have high stability and high safety. The ultraviolet absorbent and photostabilizer include a pyridazine derivative of the formula (1): ##STR1## or salts thereof. Also, described are methods for manufacturing said pyridazine derivative and/or this salts thereof comprising the process of reacting at least 10 wt % of 4,5-dichloro-3-hydroxypyridazine or 4,5-dibromo-3-hydroxypyridazine or mixtures thereof with at least 20 vol % of morpholine in reaction solution at 70.degree. C. or higher. The ultraviolet absorbents photostabilizers include said pyridazine derivative and/or salts thereof as effective ingredient. An ultraviolet ray absorption composition and an external preparation for skin are also included.
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