Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
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United States of America Patent
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Issued Date -
Aug 23, 2001
app pub date -
Dec 26, 2000
filing date -
Apr 23, 1998
priority date (Note) -
Abandoned
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Abstract
Disclosed and claimed are: epitopic regions of Pneumococcal Surface Protein C or 'PspC', different clades of PspC, isolated and/or purified nucleic acid molecules such as DNA encoding a fragment or portion of PspC such as an epitopic region of PspC or at least one epitope of PspC, uses for such nucleic acid molecules, e.g., to detect the presence of PspC or of S. pneumoniae by detecting a nucleic acid molecule therefor in a sample such as by amplification and/or a polymerase chain reaction, vectors or plasmids which contain and/or express such nucleic acid molecles, e.g., in vitro or in vivo, immunological, immunogenic or vaccine compositions including at least one PspC and/or a portion thereof (such as at least one epitopic region of at least one PspC and/or at least one polypeptide encoding at least one epitope of at least one PspC), either alone or in further combination with at least one second pneumococcal antigen, such as at least one different PspC and/or a fragment thereof and/or at least one PspA and/or at least one epitopic region of at least one PspA and/or at least one polypeptide including at least one epitope of PspA. PspC or a fragment thereof, and thus a composition including PspC or a fragment thereof, can be administered by the same routes, and in approximately the same amounts, as PspA. Thus, the invention further provides methods for administering PspC or a fragment thereof, as well as uses of PspC or a fragment thereof to formulate such compositions.
First Claim
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Patent Owner(s)
Patent Owner | Address | |
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UAB RESEARCH FOUNDATION THE | SUITE 1120G 701 SOUTH 20TH STREET BIRMINGHAM AL 35294 |
International Classification(s)
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- [Patents Count]
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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Briles, David E | Birmingham, AL | 33 | 327 |
Brooks-Walter, Alexis | Birmingham, AL | 6 | 36 |
Hollingshead, Susan K | Birmingham, AL | 9 | 76 |
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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