Alzheimer's disease secretase, APP substrates therefor, and uses therefor
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United States of America Patent
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Apr 27, 2004
Grant Date -
Aug 23, 2001
app pub date -
Feb 27, 2001
filing date -
Sep 24, 1998
priority date (Note) -
Expired
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Abstract
The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
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