PEDTIDYL-PROLYL CIS-TRANS ISOMERASE INHIBITORS AND USES THEREFORE
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United States of America Patent
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Issued Date -
Aug 23, 2001
app pub date -
Jun 9, 1998
filing date -
Jun 9, 1998
priority date (Note) -
Abandoned
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Abstract
The invention relates to inhibitors of PPIase activity and pharmaceutical compositions containing such inhibitors. Such compounds are useful for treatment of disorders characterized by inappropriate cell proliferation. In particular the compounds disclosed herein inhibit the activity of members of the Pinl/parvulin class of PPIases. These compounds have been designed based on the high resolution X-Ray derived crystal structure of the human enzyme Pin1.
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