Methods and compositions for modulating heterotypic E-cadherin interactions with T lymphocytes
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United States of America Patent
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Jun 18, 2002
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app pub date -
Mar 2, 2001
filing date -
May 3, 1994
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Abstract
The present invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding function of E-cadherin also are provided. The antibodies and peptides are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating adhesion between T lymphocytes and E-cadherin expressing cells. Methods and pharmaceutical compositions for modifying the mucosal immune response of a subject also are provided.
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