Process for the preparation of cyclosporin derivatives
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United States of America Patent
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Jun 5, 2007
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app pub date -
Dec 22, 2000
filing date -
Jun 22, 1998
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Abstract
The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or several free hydroxy groups and/or non-methylated nitrogen atoms in position .alpha. and/or any other acid group capable of deprotonation which are optionally deprotonated or in protected form.
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