Temperature-sensitive and cold-adapted human parainfluenza virus type 2 (HPIV-2) and vaccines based on such virus
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United States of America Patent
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Sep 20, 2005
Grant Date -
Oct 11, 2001
app pub date -
Feb 16, 2001
filing date -
Sep 1, 1998
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present invention relates to isolated, attenuated viral strains of human parainfluenza virus 2 (HPIV-2), which are useful in live vaccine preparations. These strains exhibit a temperature sensitive and cold adapted phenotype useful for stimulating a protective immune response in an inoculated mammal without producing severe symptoms.
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