Processes for making- and a new crystalline form of- leflunomide
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United States of America Patent
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Aug 26, 2003
Grant Date -
Oct 18, 2001
app pub date -
Dec 14, 2000
filing date -
Dec 16, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
New leflunomide Form III is disclosed, along with processes for preparing it. The present invention also provides an economic process for preparing leflunomide Form II and a process for preparing leflunomide Form I from leflunomide Form III. Pharmaceutical compositions and dosage forms containing the new form and methods of using them for the treatment of rheumatoid arthritis are also disclosed.
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